Products from AdipoGen Life Sciences
AdipoGen Life Sciences is a manufacturer of reagents for immunometabolism & advanced inflammation research. The headquarters are located in San Diego, USA with a manufacturing laboratory in Switzerland. A motivated team of highly skilled researchers develops new products for the Life Science Reagents Market in the areas cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cells and neurodegeneration. The major focus is on innovative and advanced ELISA-Kits. In addition to the antibody and protein facilities, AdipoGen also owns chemical laboratories, enabling the company to develop new and innovative biochemicals.
More information at: www.adipogen.com
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Retatrutide . sodium salt
Item number: AG-CP3-0044-M025
Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR,...
| Keywords: | LY3437943, GGG Tri-agonist |
| Application: | GCGR/GIPR/GLP-1R triple agonist peptide |
| MW: | 4754.4 D |
From 66.00€
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AOH1996
Item number: AG-CR1-3553-M025
AOH1996 is an orally available and metabolically stable small molecule PCNA inhibitor, which selectively kills cancer cells, with a median concentration of about 300 nM for 50% growth inhibition. AOH1996 was not significantly toxic to non-malignant cells, even up to 10 µM. AOH1996 enhances the interaction between...
| Keywords: | NSC789796, N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide |
| Application: | PCNA inhibitor |
| CAS | 2089314-64-5 |
| MW: | 426,5 D |
From 83.00€
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Asprosin (human) ELISA Kit
Item number: AG-45B-0010-KI01
Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to...
| Keywords: | FBN |
| Application: | ELISA |
| Species reactivity: | human |
605.00€
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Latrunculin A
Item number: AG-CN2-0027-C100
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Potent phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in...
| Keywords: | LAT-A, NSC 613011 |
| Application: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421,6 D |
From 143.00€
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Cyclosporin A (5x100mg)
Item number: AG-CN2-0079-M100
Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)) - Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B, calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells...
| Keywords: | Antibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193, Ramihyphin A |
| Application: | Immunsuppressant |
| CAS | 59865-13-3 |
| MW: | 1202,6 D |
From 55.00€
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MCC950 . Na
Item number: AG-CR1-3615-M001
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
| Keywords: | MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| Application: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426,5 D |
From 39.00€
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IL-33 (oxidation resistant) (human) (rec.) (untagged)
Item number: AG-40B-0160-C100
Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed...
| Keywords: | IL33, C9orf26, IL-33 (human) (C208S/C232S), Interleukin-33 (human) (C208S/C232S), IL-1F11, NF-HEV |
| Application: | Cell culture, binding assays |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 17 kD |
From 286.00€
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Actinomycin D
Item number: BVT-0089-M005
Antibiotic, Antitumor compound, Cytotoxic, Apoptosis inducer, RNA synthesis inhibitor, DNA intercalating agent, Mcl-1 expression inhibitor, p53 pathway activator. Isolated from Streptomyces parvulus.
| Keywords: | Actinomycin IV, Actinomycin C1, Dactinomycin |
| Application: | p53 pathway activator |
| CAS | 50-76-0 |
| MW: | 1255,4 D |
From 55.00€
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Arginase I (human) (rec.) (highly active)
Item number: AG-40T-0124-C010
Protein function: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively, the urea cycle takes place primarily in the liver...
| Keywords: | ARG1, Arginase-1, Type I arginase, Liver-type arginase |
| Expressed in: | E.coli |
| Origin: | human |
From 286.00€
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Gasdermin D (mouse) ELISA Kit
Item number: AG-45B-0011-KI01
Detects full-length and cleaved mouse Gasdermin D (C-terminus) in cell culture supernatants and cell extracts. Does not cross-react with human gasdermin D. Sensitivity: 14pg/ml. Range: 15.6 to 1000pg/ml. Protein function: Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger...
| Keywords: | Gsdmd, Gsdmdc1, Gasdermin Domain-containing Protein 1, Gasdermin-D (C-terminal), GSDMD-CT |
| Application: | ELISA |
| Species reactivity: | mouse |
660.00€
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Flagellin (high purity)
Item number: AG-40B-0025-3010
(3 x 10µg). Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens...
| Keywords: | FliC |
| Application: | Bioassays |
| Origin: | human, mouse |
From 198.00€
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(-)-Viriditoxin
Item number: AG-CN2-0471-C500
Solid. Soluble in DMSO or ethanol. Antibiotic. Exhibits broad activity against Gram-positive bacteria, Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml), Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate...
| Keywords: | (M)-Viriditoxin, SC-28762 |
| Application: | Antibiotic (Gram-positive bacteria), FtsZ inhibitor |
| CAS | 1381782-08-6 |
| MW: | 662,6 D |
154.00€
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