Tumor Necrosis Factor beta, His Tag, human recombinant (rHuTNF-b-His)

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 171 amino acids (fragment 35-205) with an amino-terminal hexahistidine tag.