Thymus and Activation Regulated Chemokine (CCL17), human recombinant (rHuTARC)

Thymus and Activation Regulated Chemokine (CCL17), human recombinant (rHuTARC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97329.5 5 µg - -

3 - 10 Werktage*

94,00 €
97329.20 20 µg - -

3 - 10 Werktage*

208,00 €
97329.1 1 mg - -

3 - 10 Werktage*

3.952,00 €
 
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell... mehr
Produktinformationen "Thymus and Activation Regulated Chemokine (CCL17), human recombinant (rHuTARC)"
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. (www.uniprot.org) Recombinant human CCL17 produced in E.coli is a single,non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa. TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1alpha, MIP-1beta, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Schlagworte: C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273
Hersteller: Biomol GmbH
Hersteller-Nr: 97329

Eigenschaften

Anwendung: Cell culture
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human
MW: 8000 D
Format: Purified

Datenbank Information

KEGG ID : K21083 | Passende Produkte
UniProt ID : Q92583 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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