Artikelnummer | Größe | Datenblatt | Manual | SDB | Lieferzeit | Menge | Preis |
---|---|---|---|---|---|---|---|
97332.1 | 1 µg | - | - |
3 - 10 Werktage* |
94,00 €
|
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97332.5 | 5 µg | - | - |
3 - 10 Werktage* |
208,00 €
|
||
97332.50 | 50 µg | - | - |
3 - 10 Werktage* |
1.602,00 €
|
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Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. (www.uniprot.org) Recombinant human CXCL4 Variant-1 produced in E.coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Schlagworte: | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298 |
Hersteller: | Biomol GmbH |
Hersteller-Nr: | 97332 |
Eigenschaften
Anwendung: | Bioassay |
Konjugat: | No |
Wirt: | E.coli |
Spezies-Reaktivität: | human |
MW: | 8700 D |
Format: | Purified |
Datenbank Information
KEGG ID : | K05407 | Passende Produkte |
UniProt ID : | P02776 | Passende Produkte |
Handhabung & Sicherheit
Lagerung: | -20°C |
Versand: | +4°C (International: +4°C) |
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!