Placenta Growth Factor-1, human recombinant (rHuPLGF-1)

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. (www.uniprot.org) Produced in insect cells. Homodimer, glycosylated polypeptide chain containing 2 x 131 amino acids. The ED50 as determined by its ability to bind to immobilized rh-sFlt-1 in a functional ELISA.