Osteoclast stimulating factor 1 (OSTF1, SH3P2, OSF), 1-217aa, human recombinant (rHuOSTF1)

Osteoclast-stimulating factor-1 (OSTF1) is an intracellular protein produced by osteoclasts that indirectly induces osteoclast (OCL) formation and bone resorption. OSTF1 is highly expressed in OCL and contains structural domains such as SH3 and ankyrin repeats, which are potentially involved in protein-protein interactions. OSTF1 is ubiquitously expressed analogous to other regulators of OCL activity such as c-Src or transforming growth factor beta. Source Recombinant human OSTF1 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. AA Sequence: MSKPPPKPVK PGEGGQVKVF RALYTFEPRT PDELYFEEGD IIYITDMSDT NWWKGTSKGR TGLIPSNYVA EQAESIDNPL HEAAKRGNLS, WLRECLDNRV GVNGLDKAGS TALYWACHGG HKDIVEMLFT QPNIELNQQN KLGDTALHAA AWKGYADIVQ LFLAKGARTD LRNIEKKLAF , DMATNAACAS LLKKKQGTDA VRTLSNAEDY LDDEDSDLEH HHHHH, Molecular Weight: 25.1kD (225aa) , Storage and Stability:, For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.