Interleukin-22, rat recombinant (rrIL-22)

Rat recombinant IL-22 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of 16.6kDa. IL-22 is a member of the IL-10 family of regulatory cytokines. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T-lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.