Insulin-Like Growth Factor Binding Protein-1, human (rHuIGFBP-1)

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. (www.uniprot.org) Produced in NSO cells. Single glycosylated polypeptide chain, 218 amino acids. Inhib. of IGF-I stimulated prolif. of NUC-1 cells: IC50 ~100 ng/ml. Inhib. of serum-induced stimulation of DNA synthesis in chick embryo fibroblast: IC50 ~300 ng/ml.