IL-31, Mouse

Sequence: MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL NPLNLNISVP GNTDESYDCK VFVLTVLKQF SNCMAELQAK with polyhistidine tag at the Cterminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241). [The UniProt Consortium]