IL-31, Human

Sequence: MSHTLPVRLL RPSDDVQKIV EELQSLSKML LKDVEEEKGV LVSQNYTLPC LSPDAQPPNN IHSPAIRAYL KTIRQLDNKS VIDEIIEHLD APETNISVPT DTHECKRFIL TISQQFSECM DLALKSLTSG with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. [The UniProt Consortium]