Human Noggin, Fc tag, HEK293

Sequence: QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP EIKGLEFSEG LAQGKKQRLS KKLRRKLQMW LWSQTFCPVL YAWNDLGSRF WPRYVKVGSC FSKRSCSVPE GMVCKPSKSV RRGGQRCGWI PIQYPIISEC Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). [The UniProt Consortium]