Growth and Differentiation Factor-5, human recombinant (rHuGDF-5)

Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. (www.uniprot.org) Produced in E.coli. Homodimer, non-glycosylated, polypeptide chain containing 2 x 117 amino acids. To enable bacterial expression of rhGDF-5 we removed the N-terminal sequence Ala-Pro-Leu-Thr and added the Lys.