Galectin-3, His Tag, human recombinant (rHuGAL3-His)

Galectin-3, His Tag, human recombinant (rHuGAL3-His)
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97308.5 5 µg - -

1 - 10 Werktage

70,00 €
97308.25 25 µg - -

1 - 10 Werktage

180,00 €
97308.1 1 mg - -

1 - 10 Werktage

-
 
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the... mehr
Produktinformationen "Galectin-3, His Tag, human recombinant (rHuGAL3-His)"

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. (www.uniprot.org) Human recombinant LGALS3 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (fragment 1-250) and having a molecular mass of 28.2 kDa. The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus. Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.

Schlagworte: Galectin-3, GAL3, MAC2, CBP35, GALB, GALIG, LGALS2, LGALS3, Galactose-specific lectin 3, Mac-2 antigen, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, G
Hersteller: Biomol GmbH
Hersteller-Nr: 97308.1

Eigenschaften

Anwendung: Bioassay
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 28200 D
Reinheit: >95%
Format: Purified

Datenbank Information

KEGG ID : K06831 | Finde Alternativen
UniProt ID : P17931 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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