Fibroblast Growth Factor-23, His Tag, human recombinant (rHuFGF-23-His)

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 243 amino acids.