FGF-19, Human

Sequence: MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LQYSEEDCAF EEEIRPDGYN VYRSEKHRLP VSLSSAKQRQ LYKNRGFLPL SHFLPMLPMV PEEPEDLRGH LESDMFSSPL ETDSMDPFGL TGLEAVRSPS with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. [The UniProt Consortium]