FasL, Mouse

Sequence: QIANPSTPSE KKEPRSVAHL TGNPHSRSIP LEWEDTYGTA LISGVKYKKG GLVINETGLY FVYSKVYFRG QSCNNQPLNH KVYMRNSKYP VLMEEKRLNY CTTGQIWAHS SYLGAVFNLT SADHLYVNIS QLSLINFEES with polyhistidine tag and sumo tag at the N-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [The UniProt Consortium]