DKK1 protein (His tag), recombinant mouse

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Mouse DKK1 protein (O54908) (Met1-His272) was expressed with a C-His. Sequence: Met1-His272. Fusion tag: C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 40 kDa. Protein function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independe Protein function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development, attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822). [The UniProt Consortium]