CCL1/I-309 Protein (recombinant human)

Protein Construction: Recombinant Human C-C Motif Chemokine 1 is produced by our E.coli expression system and the target gene encoding Lys24-Lys96 is expressed. Sequence: Lys24-Lys96. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 10 kDa. Protein function: Chemokine (C-C Motif) Ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells, which play a central role during immunoregulatory and inflammaion processes. Human CCL1 has been assumed to be a homologue of the mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with cell surface chemokine receptor CCR8. CCL1 is identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. Protein function: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. [The UniProt Consortium]