BMP-8a, Human

Sequence: MAVRPLRRRQ PKKSNELPQA NRLPGIFDDV HGSHGRQVCR RHELYVSFQD LGWLDWVIAP QGYSAYYCEG ECSFPLDSCM LVHLMKPNAV PKACCAPTKL SATSVLYYDS SNNVILRKHR with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. [The UniProt Consortium]