
Preis anfragen
Artikelnummer | Größe | Datenblatt | Manual | SDB | Lieferzeit | Menge | Preis |
---|---|---|---|---|---|---|---|
97377.5 | 5 µg | - | - | 3 - 10 Werktage* | 71,00 € | ||
97377.20 | 20 µg | - | - | 3 - 10 Werktage* | 184,00 € | ||
97377.1 | 1 mg | - | - | 3 - 10 Werktage* | - |
Größere Menge gewünscht? Bulk-Anfrage
Recombinant human CXCL13 produced in E.coli is a single,non-glycosylated, polypeptide chain containing 87 amino acids and having a molecular mass of 10.3 kDa. BCA-1 is a CXC chemokine that is highly expressed in the secondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt's lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.
Schlagworte: | C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2. |
Hersteller: | Biomol GmbH |
Hersteller-Nr: | 97377.1 |
Eigenschaften
Anwendung: | Bioassay |
Konjugat: | No |
Exprimiert in: | E.coli |
Ursprungsart: | Human |
MW: | 10300 D |
Format: | Purified |
Datenbank Information
KEGG ID : | K10032 | Finde Alternativen |
UniProt ID : | O43927 | Finde Alternativen |
Gene ID | GeneID 10563 | Finde Alternativen |
Handhabung & Sicherheit
Lagerung: | -20°C |
Versand: | +20°C (International: +20°C) |
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!