B-Cell Maturation Antigen, His tag, human recombinant (rHuTNFRS17-His)

B-Cell Maturation Antigen, His tag, human recombinant (rHuTNFRS17-His)
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Preis anfragen

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97632.5 5 µg - -

1 - 10 Werktage

70,00 €
97632.20 20 µg - -

1 - 10 Werktage

180,00 €
97632.1 1 mg - -

1 - 10 Werktage

-
 
TNFRSF17 human recombinant produced in E.coli is a single, non-glycosylated polypeptide chain... mehr
Produktinformationen "B-Cell Maturation Antigen, His tag, human recombinant (rHuTNFRS17-His)"

TNFRSF17 human recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (78-184) and having a molecular mass of 14.1 kDa. TNFRSF17 is fused to a 21 amino acid His-tag at N-terminus. TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.

Schlagworte: BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen.
Hersteller: Biomol GmbH
Hersteller-Nr: 97632.1

Eigenschaften

Anwendung: Bioassays
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 14100 D
Reinheit: >90%
Format: Liquid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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