Recombinant Mouse Axl Kinase Protein (His Tag) (RPES3699)

Recombinant Mouse Axl Kinase Protein (His Tag) (RPES3699)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3699.50 50 µg - - -

9 - 20 Werktage*

562,00 €
 
Recombinant Mouse Axl Kinase Protein (His Tag) from Assay Genie. Recombinant Mouse Axl Kinase... mehr
Produktinformationen "Recombinant Mouse Axl Kinase Protein (His Tag) (RPES3699)"
Recombinant Mouse Axl Kinase Protein (His Tag) from Assay Genie. Recombinant Mouse Axl Kinase Protein (His Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [The UniProt Consortium]
Schlagworte: Ark, Axl, EC=2.7.10.1, Adhesion-related kinase, Tyrosine-protein kinase receptor UFO
Hersteller: Assay Genie
Hersteller-Nr: RPES3699

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

KEGG ID : K05115 | Passende Produkte
UniProt ID : Q00993 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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