Zu "K05115" wurden 172 Artikel gefunden!
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Anti-Recombinant Axl, clone 5A10
Artikelnummer: E-AN300623L.100
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the...
| Schlagworte: | Anti-AXL, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO, Recombinant Axl Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Axl Extracellular Domain (human, recombinant)
Artikelnummer: Cay44185-100
Axl is a receptor tyrosine kinase and member of the TAM kinase family. It is composed of two immunoglobulin-like (Ig-like) domains, two fibronectin-like III domains, an extracellular cleavage site, a transmembrane region, and a C-terminal kinase domain. It is ubiquitously expressed and localizes to the cell...
| Schlagworte: | UFO |
| Anwendung: | Active protein |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
206,00 €
Mouse AXL ELISA Kit
Artikelnummer: ARG81697.96
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | Ark, Axl, EC=2.7.10.1, Adhesion-related kinase, Tyrosine-protein kinase receptor UFO |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
Human AXL ELISA Kit
Artikelnummer: ARG81696.96
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | UFO, AXL, EC=2.7.10.1, AXL oncogene, Tyrosine-protein kinase receptor UFO |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
R428
Artikelnummer: Cay21523-1
R428 is a small molecule inhibitor of Axl kinase, both in an in vitro biochemical assay and in a cell-based assay using phosphorylation of Ser473 on Akt as the readout (EC50s = 14 nM for both). It is orally bioavailable, blocks angiogenesis in corneal micropocket and tumor models, and reduces metastatic burden while...
| Schlagworte: | Bemcentinib, BGB 324,... |
| Anwendung: | Axl kinase inhibitor |
| CAS | 1037624-75-1 |
| MW: | 506.6 D |
ab 40,00 €
Gilteritinib
Artikelnummer: Cay21503-1
Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations...
| Schlagworte: | ASP2215,... |
| Anwendung: | FLT3 / AXL inhibitor |
| CAS | 1254053-43-4 |
| MW: | 552.7 D |
ab 51,00 €
SGI-7079
Artikelnummer: Cay20111-1
SGI-7079 is an inhibitor of the receptor tyrosine kinase Axl. It inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively), decreases invasion, and halts the cell cycle in the G1 phase. SGI-7079 synergistically increases the potency of erlotinib...
| Schlagworte: | 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-benzeneacetonitrile |
| Anwendung: | Axl inhibitor |
| CAS | 1239875-86-5 |
| MW: | 455.5 D |
ab 51,00 €
AXL Kinase Assay Kit
Artikelnummer: BPS-79711
The AXL Kinase Assay Kit is designed to measure AXL kinase activity for screening and profiling applications using ADP-Glo(R) Kinase Assay as a detection reagent. The AXL Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant AXL enzyme, AXL substrate, ATP and kinase assay buffer for...
| Schlagworte: | AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
Cabozantinib S-malate
Artikelnummer: CDX-C0698-M500
The s-malate salt form of Cabozantinib is very potent orally available inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of...
| Schlagworte: | XL184 malate, BMS907351 malate,... |
| Anwendung: | Multiple receptor tyrosine kinase (MET/VEGFR2) inhibitor |
| CAS | 1140909-48-3 |
| MW: | 635.59 D |
ab 140,00 €
Anti-Axl
Artikelnummer: A302-167A
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | Anti-UFO, Anti-AXL, EC=2.7.10.1, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-Axl
Artikelnummer: A302-168A
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | Anti-UFO, Anti-AXL, EC=2.7.10.1, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Axl, active human recombinant protein
Artikelnummer: BPS-40180
Active AXL (GenBank Accession No. NM_021913), (a.a. 473-894) with N-terminal GST tag, MW= 77 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | UFO, AXL, AXL oncogene, Tyrosine-protein kinase receptor UFO, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 77 kD |
536,00 €