Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) (RPES3925)

Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) (RPES3925)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3925.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) (RPES3925)"
Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant Human TrkA/NTRK1 Protein (His & Fc Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin- 3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand- binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. [The UniProt Consortium]
Schlagworte: NTRK1, Trk-A, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A, TRK1-transforming tyrosine kinase protein, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1
Hersteller: Assay Genie
Hersteller-Nr: RPES3925

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K03176 | Passende Produkte
UniProt ID : P04629 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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