Zu "K03176" wurden 126 Artikel gefunden!
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GW 441756
Artikelnummer: Cay16915-1
The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis. GW 441756 is a potent...
| Schlagworte: | 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one |
| Anwendung: | TrkA inhibitor |
| CAS | 504433-23-2 |
| MW: | 275.3 D |
ab 32,00 €
Anti-Pan TRK / TrkA/B/C, clone RM423
Artikelnummer: NSJ-R20437-0.1ML
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity...
| Schlagworte: | Anti-NTRK1, Anti-Trk-A, Anti-gp140trk, Anti-p140-TrkA, Anti-Tyrosine kinase receptor, Anti-Tyrosine kinase receptor A,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
737,00 €
Lestaurtinib
Artikelnummer: Cay12094-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | A 154475.0, CEP-701, KT 5555, SP 924,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 111358-88-4 |
| MW: | 439.5 D |
ab 60,00 €
GW-441756
Artikelnummer: SYN-1044-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner. Target: TrkA , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | GW441756 |
| Anwendung: | TrkA inhibitor |
| CAS | 504433-23-2 |
| MW: | 275,3 D |
ab 79,00 €
Entrectinib
Artikelnummer: Cay19476-10
Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1, IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK, IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance...
| Schlagworte: | NMS-E628, RXDX-101,... |
| Anwendung: | TrkA/B/C inhibitor |
| CAS | 1108743-60-7 |
| MW: | 560.6 D |
ab 48,00 €
LOXO-101
Artikelnummer: Cay27056-5
LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 µM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = In vivo, LOXO-101 (60 and 200 mg/kg)...
| Schlagworte: | ARRY-470, Larotrectinib,... |
| Anwendung: | TrkA / TrkB / TrkC inhibitor |
| CAS | 1223403-58-4 |
| MW: | 428.4 D |
ab 60,00 €
Anti-phospho-TrkA (Ser791)
Artikelnummer: ARG51798.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind...
| Schlagworte: | Anti-phospho-MTC, Anti-phospho-Trk-A, Anti-phospho-NTRK1, Anti-phospho-gp140trk, Anti-phospho-p140-TrkA, EC=2.7.10.1,... |
| Anwendung: | ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 436,00 €
TRKA, active human recombinant protein
Artikelnummer: BPS-40280
Active recombinant human TRKA (440-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. The gene accession number is NM_002529.
| Schlagworte: | Trk-A, NTRK1, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 66 kD |
525,00 €
Mouse Ntrk1 / TrkA ELISA Kit
Artikelnummer: G-MOFI00183.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
694,00 €
Human TrkA ELISA Kit
Artikelnummer: KOA0508
Natural and recombinant human TrkA. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of...
| Schlagworte: | MTC, NTRK1, Trk-A, gp140trk, p140-TrkA, EC=2.7.10.1, Tyrosine kinase receptor, Tyrosine kinase receptor A,... |
| Anwendung: | ELISA |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
958,00 €
Rat TrkA ELISA Kit
Artikelnummer: KOA0509
Natural and recombinant rat TrkA. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of...
| Schlagworte: | Trk, Trk-A, Ntrk1, p140-TrkA, EC=2.7.10.1, Slow nerve growth factor receptor, High affinity nerve growth factor receptor,... |
| Anwendung: | ELISA |
| Wirt: | Rat |
| Spezies-Reaktivität: | rat |
958,00 €
Anti-TrkA (NTRK1)
Artikelnummer: NSJ-R31268
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Neurotrophic tyrosine kinase receptor type 1, also called TrkA, is a protein that in humans is encoded by the NTRK1 gene. The NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors whose ligands...
| Schlagworte: | Anti-MTC, Anti-Trk-A, Anti-NTRK1, Anti-gp140trk, Anti-p140-TrkA, EC=2.7.10.1, Anti-Tyrosine kinase receptor, Anti-Tyrosine... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €