Zu "K03176" wurden 150 Artikel gefunden!
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Anti-Recombinant Trk pan, clone 6H8
Artikelnummer: E-AN300735L.100
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory...
| Schlagworte: | Anti-NTRK1, Anti-gp140trk, Anti-p140-TrkA, Anti-Tyrosine kinase receptor, Anti-Tyrosine kinase receptor A,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant Trk A, clone 4D4
Artikelnummer: E-AN301287L.100
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory...
| Schlagworte: | Anti-NTRK1, Anti-gp140trk, Anti-p140-TrkA, Anti-Tyrosine kinase receptor, Anti-Tyrosine kinase receptor A,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant Phospho-TrkA (Y791), clone A460
Artikelnummer: E-AN301752L.100
NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with NTRK1 include Insensitivity to Pain, Congenital, With Anhidrosis and Thyroid Carcinoma, Familial Medullary. Among its related pathways are PI3K/AKT activation and p70S6K Signaling.
| Schlagworte: | Anti-NTRK1, Anti-gp140trk, Anti-p140-TrkA, Anti-Tyrosine kinase receptor, Anti-Tyrosine kinase receptor A,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Human TrkA ELISA Kit
Artikelnummer: ARG81758.96
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821,...
| Schlagworte: | NTRK1, Trk-A, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
TrkA, His, Human
Artikelnummer: GSC-Z05926-100
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.
| Schlagworte: | NTRK1, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A,... |
| Ursprungsart: | human |
| MW: | 43 kD |
ab 457,00 €
TrkA, Human
Artikelnummer: GSC-Z03106-1
Tyrosine kinase receptor A (Trk-A) is a member of the neurotrophic tyrosine kinase receptor family which includes three members: Trk-A, Trk-B and Trk-C. Trk-A is involved in the development and maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival...
| Schlagworte: | NTRK1, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A,... |
| Ursprungsart: | human |
ab 67,00 €
Anti-TrkA/NTRK1 Monoclonal Recombinant Antibody
Artikelnummer: E-AN300218P.100
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory...
| Schlagworte: | Trk-A, NTRK1, gp140trk, p140-TrkA, Tyrosine kinase receptor, Tyrosine kinase receptor A, Tropomyosin-related kinase A,... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
462,00 €
Lestaurtinib
Artikelnummer: Cay12094-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | A 154475.0, CEP-701, KT 5555, SP 924,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 111358-88-4 |
| MW: | 439.5 D |
ab 67,00 €
Entrectinib
Artikelnummer: Cay19476-10
Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1, IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK, IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance...
| Schlagworte: | NMS-E628, RXDX-101,... |
| Anwendung: | TrkA/B/C inhibitor |
| CAS | 1108743-60-7 |
| MW: | 560.6 D |
ab 54,00 €
GW-441756
Artikelnummer: SYN-1044-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner. Target: TrkA , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | GW441756 |
| Anwendung: | TrkA inhibitor |
| CAS | 504433-23-2 |
| MW: | 275,3 D |
ab 92,00 €
LOXO-101
Artikelnummer: Cay27056-5
LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 µM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = In vivo, LOXO-101 (60 and 200 mg/kg)...
| Schlagworte: | ARRY-470, Larotrectinib,... |
| Anwendung: | TrkA / TrkB / TrkC inhibitor |
| CAS | 1223403-58-4 |
| MW: | 428.4 D |
ab 67,00 €
Anti-phospho-TrkA (Ser791)
Artikelnummer: ARG51798.100
Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind...
| Schlagworte: | Anti-phospho-MTC, Anti-phospho-Trk-A, Anti-phospho-NTRK1, Anti-phospho-gp140trk, Anti-phospho-p140-TrkA, EC=2.7.10.1,... |
| Anwendung: | ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 471,00 €