Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) (RPES4221)

Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) (RPES4221)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4221.50 50 µg - - -

9 - 20 Werktage*

562,00 €
 
Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) (RPES4221)"
Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) from Assay Genie. Recombinant Human c-KIT/CD117 Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. [The UniProt Consortium]
Schlagworte: KIT, PBT, SCFR, CD117, p145 c-kit, EC=2.7.10.1, Proto-oncogene c-Kit, Piebald trait protein, Tyrosine-protein kinase Kit, Mast/stem cell growth factor receptor Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Hersteller: Assay Genie
Hersteller-Nr: RPES4221

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05091 | Passende Produkte
UniProt ID : P10721 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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