Prorenin (human, recombinant)

Prorenin is the inactive precursor of renin, which is a key enzyme in the regulation of blood pressure and electrolyte balance. In renal juxtaglomerular cells, sequential cleavage of the N-terminal 20 and 46 amino acids of preprorenin produces prorenin and active renin, respectively. Renin catalyzes the conversion of angiotensinogen to angiotensin I. Prorenin exhibits 5-10% of the proteolytic activity of renin, however, the blood circulating levels are 10 times higher.Synonyms: Angiotensinogenase, Angiotensin forming enzyme. Purity: >90% estimated by SDS-PAGE. Source: Recombinant enzyme expressed in HEK cells. Amino Acids: 1-406 (full length). MW: 45 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 5% glycerol. UniProt Accession #: P00797.