PRIM1 PrEST Antigen

PRIM1 PrEST Antigen
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-APrEST81248.100 100 µl - -

7 - 10 Werktage*

247,00 €
 
Protein function: Catalytic subunit of the DNA primase complex and component of the DNA... mehr
Produktinformationen "PRIM1 PrEST Antigen"
Protein function: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Can add both ribo- and deoxynucleotides during elongation of the primers. Binds single stranded DNA. [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
Schlagworte: p49, PRIM1, DNA primase small subunit, DNA primase 49 kDa subunit
Hersteller: Atlas Antibodies
Hersteller-Nr: APrEST81248

Eigenschaften

Anwendung: Control antigen
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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