Spironolactone-d3

Spironolactone-d3 is intended for use as an internal standard for the quantification of spironolactone by GC- or LC-MS. Spironolactone is a steroidal mineralocorticoid receptor antagonist (IC50 = 24 nM) and a diuretic. It is selective for the mineralocorticoid receptor over the glucocorticoid receptor (IC50 = 2,410 nM) but also binds to the androgen receptor and progesterone receptor (IC50s = 77 and 743 nM, respectively). In vivo, spironolactone (37.5 mg/kg per day) administered in combination with lisinopril preserves ejection fraction in mice and reduces myocardial fibrosis in a mouse model of Duchenne muscular dystrophy (DMD). Formulations containing spironolactone have been used in the treatment of hypertension and heart failure.Formal Name: S-((7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl-2,2,4-d3) ethanethioate. Molecular Formula: C24H29D3O4S. Formula Weight: 419.6. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](SC(C)=O)CC5=C([2H])C(C([2H])([2H])C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O. InChi Code: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1/i4D2,12D. InChi Key: LXMSZDCAJNLERA-RQPNHFSDSA-N.