Zu "K08555" wurden 80 Artikel gefunden!
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MR (human) Reporter Assay Kit
Artikelnummer: IB-IB00502
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO's reporter cells include the luciferase...
| Schlagworte: | MR, MCR, NR3C2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
Spironolactone-d3
Artikelnummer: Cay43592-1
An internal standard for the quantification of spironolactone by GC- or LC-MS. Formulation: A solid. InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1/i1D3. InChIKey:...
| Schlagworte: | SC-9420-d3, (7alpha,17alpha)-7-(acetylthio-d3)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid-gamma-lactone |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, steroidal mineralocorticoid receptor antagonist |
| MW: | 419.59 D |
809,00 €
Corticosterone
Artikelnummer: Cay16063-1
Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress,...
| Schlagworte: | 11beta,21-DHP, 11beta,21-dihydroxy Progesterone, 17-deoxy Cortisol, NSC 9705, 11beta,21-dihydroxy-pregn-4-ene-3,20-dione |
| Anwendung: | Steroid hormone, aldosterone precursor, stress biomarker, mineralocorticoid receptor agonist |
| CAS | 50-22-6 |
| MW: | 346.5 D |
ab 49,00 €
Aldosterone
Artikelnummer: Cay15273-500
Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance. Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal...
| Schlagworte: | 18-Aldocorticosterone, NSC 73856, Reichstein X, 11beta,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| Anwendung: | Steroid hormone, mineralocorticoid hormone |
| CAS | 52-39-1 |
| MW: | 360.4 D |
ab 75,00 €
![Aldosterone-[2,2,4,6,6,17,21,21-2H7]](https://www.biomol.com/media/image/5c/8a/39/ISO-S5093-100_200x200.png "Aldosterone-[2,2,4,6,6,17,21,21-2H7]")
Aldosterone-[2,2,4,6,6,17,21,21-2H7]
Artikelnummer: ISO-S5093.100
Isotope Incorporation: >98%
| Schlagworte: | Deuterium-labelled, CAS of labelled compound: 1261254-31-2, Aldosterone-[2,2,4,6,6,17,21,21-2H8] |
| Anwendung: | Mineralocorticoid receptor agonist, LC/MS internal standard |
| CAS | 52-39-1 |
648,00 €
11-deoxy Corticosterone
Artikelnummer: Cay22916-25
11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland. It is a metabolite of progesterone (Cay-15876) and precursor to aldosterone (Cay-15273) and corticosterone (Cay-16063). DOC is metabolized to the neuroactive compound...
| Schlagworte: | 21-hydroxy Progesterone, DOC, NSC 11319, 21-hydroxy-pregn-4-ene-3,20-dione |
| Anwendung: | Endogenous mineralocorticoid |
| CAS | 64-85-7 |
| MW: | 330.5 D |
ab 83,00 €
MR (human) Reporter Assay Kit
Artikelnummer: IB-IB00501
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO's reporter cells include the luciferase...
| Schlagworte: | MR, MCR, NR3C2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Corticosterone
Artikelnummer: LKT-C5771.250
Endogenous steroid hormone involved in immune response and energy homeostasis, mineralocorticoid and glucocorticoid agonist.
| Schlagworte: | Kendall's compound B, Reichstein's substance H, Compound B, (11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione |
| Anwendung: | Endogenous steroid hormone, mineralocorticoid & glucocorticoid agonist |
| CAS | 50-22-6 |
| MW: | 346.46 D |
ab 68,00 €
Eplerenone
Artikelnummer: LKT-E6245.10
Eplerenone displays antihypertensive, anti-inflammatory, and anti-angiogenic activities, it inhibits the mineralocorticoid receptor. Eplerenone inhibits aldosterone-induced expression of COX (therefore decreasing PGE2 levels), preventing the induction of COX and resulting kidney damage in high salt diets. This...
| Anwendung: | Mineralocorticoid receptor antagonist |
| CAS | 107724-20-9 |
| MW: | 414.29 D |
ab 159,00 €
Spironolactone
Artikelnummer: LKT-S6235.1
Mineralocorticoid, aldosterone, AR antagonist, ENaC channel blocker, potential voltage-gated Ca2+ channel blocker.
| Schlagworte: | Spirolactone, Spiroctan, Aldactone, (7alpha,17alpha)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4- ene-21-carboxylic acid... |
| Anwendung: | Aldosterone antagonist |
| CAS | 52-01-7 |
| MW: | 416,57 D |
ab 100,00 €
Fludrocortisone
Artikelnummer: Cay29391-5
Fludrocortisone is a synthetic mineralocorticoid. Dietary administration of fludrocortisone (10 µg/kg per day) reduces tympanic membrane thickness and fluid area in a mouse model of S. pneumoniae-induced middle ear inflammation. Formulations containing fludrocortisone have been used in the treatment of Addison's...
| Schlagworte: | 9alpha-Fludrocortisone, Astonin-H, Fluohydrocortisone, Fluorohydrocortisone, NSC 11318,... |
| Anwendung: | Synthetic mineralocorticoid, antiinflammatory |
| CAS | 127-31-1 |
| MW: | 380.5 D |
ab 49,00 €
Eplerenone
Artikelnummer: Cay15616-10
Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced...
| Schlagworte: | (+)-Eplerenone, CGP 30083, Epoxymexrenone, SC-6110, SC-66110,... |
| Anwendung: | Mineralocorticoid receptor antagonist |
| CAS | 107724-20-9 |
| MW: | 414.5 D |
ab 93,00 €