Prednisolone-d7

Prednisolone-d7 is intended for use as an internal standard for the quantification of prednisolone (Cay-20866) by GC- or LC-MS. Prednisolone is a glucocorticoid and mineralocorticoid receptor agonist and an active metabolite of the prodrugs and synthetic glucocorticoids prednisolone phosphate (Cay-15933) and prednisone (Cay-20677). It selectively binds to the glucocorticoid and mineralocorticoid receptors over the progesterone, androgen, and estrogen receptors (Kis = 2.4, 37, >5,000, 2,762, and >1,000 nM, respectively) and induces transactivation in reporter assays using CV-1 cells expressing the human glucocorticoid receptor or human mineralocorticoid receptor (EC50s = 6.9 and 3.78 nM, respectively). Prednisolone reduces pulmonary eosinophil infiltration in a rat model of sephadex-induced asthma (ED50 = 1.2 mg/kg). Formulations containing prednisolone have been used as anti-inflammatory or immunosuppressive agents.Formal Name: 11beta,17,21-trihydroxy-pregna-1,4-diene-3,20-dione-2,4,6,9,11,12,12-d7. Molecular Formula: C21H21O5D7. Formula Weight: 367.5. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@@](C1([2H])[2H])([2H])O)([2H])[C@@]4(C(C([2H])C3)=C([2H])C(C([2H])=C4)=O)C. InChi Code: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i3D,5D,9D,10D2,16D,18D/t3?,14-,15-,16-,18+,19-,20-,21-. InChi Key: OIGNJSKKLXVSLS-WHQBPOJCSA-N.