Betaxolol-d7 (hydrochloride)

Betaxolol-d7 is intended for use as an internal standard for the quantification of betaxolol (Cay-18625) by GC- or LC-MS. Betaxolol is an antagonist of the beta1-adrenergic receptor (beta1-AR, Ki = 23 nM). It is selective for the beta1-AR over the beta2-AR (Ki = 790 nM). Betaxolol is cytotoxic to 10.014 pRSV-T human corneal epithelial cells. It reduces intraocular pressure in cynomolgus monkeys with ocular hypertension induced by laser trabeculoplasty when administered at a dose of 150 µg/animal. Betaxolol also inhibits sodium influx induced by the neurotoxin veratridine in rat cortical synaptosomes (IC50 = 28.3 µM).Formal Name: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((propan-2-yl-d7)amino)propan-2-ol, monohydrochloride. CAS Number: 1219802-92-2. Molecular Formula: C18H22D7NO3 . HCl. Formula Weight: 350.9. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble, Water: Slightly soluble. SMILES: [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(O)COC1=CC=C(C=C1)CCOCC2CC2.Cl. InChi Code: InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16,/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3,1H/i1D3,2D3,14D,. InChi Key: CHDPSNLJFOQTRK-LBRFFFIWSA-N.