6beta-Naltrexol

6beta-Naltrexol (Cay-15896) is an analytical reference material that is structurally categorized as an opioid. It is the major metabolite of naltrexone (Cay-ISO60192, Cay-15520). Unlike naltrexone, which acts as a µ-receptor antagonist or inverse agonist, 6beta-naltrexol is a neutral opioid antagonist. 6beta-Naltrexol binds the µ-opioid receptor more potently than naloxone (Cay-ISO60191, Cay-15594) or naltrexone (Kis = 94, 420, and 265 pM, respectively) but is ~100-fold less effective at blocking morphine-modulated pain in vivo, as assessed using the mouse hotplate test. This product is intended for research and forensic applications.Formal Name: (5alpha,6beta)-17-(cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol. CAS Number: 49625-89-0. Molecular Formula: C20H25NO4. Formula Weight: 343.4. Purity: >98%. Formulation: (Request formulation change), A neat solid. SMILES: O[C@]12[C@]3(CCN(CC4CC4)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])[C@H](O)CC1. InChi Code: InChI=1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1. InChi Key: JLVNEHKORQFVQJ-PYIJOLGTSA-N.