Sphinganine-1-phosphate (d18:0)

Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.Formal Name: 2(S)-amino-1,3(R)-octadecanediol, 1-(dihydrogen phosphate). CAS Number: 19794-97-9. Synonyms: C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate. Molecular Formula: C18H40NO5P. Formula Weight: 381.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.3 M NaOH: 4 mg/ml, DMF: <50 µg/ml, DMSO: <50 µg/ml, Ethanol: <50 µg/ml, PBS (pH 7.2): <50 µg/ml. SMILES: N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(O)(O)=O. InChi Code: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1. InChi Key: YHEDRJPUIRMZMP-ZWKOTPCHSA-N.