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Zu "K04288" wurden 66 Artikel gefunden!
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Artikelnummer: ELK-ELK6137.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse S1PR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse S1PR1. Next,...
Schlagworte: | S1P1, Edg1, CD363, S1P receptor 1, S1P receptor Edg-1, Lysophospholipid receptor B1, Sphingosine 1-phosphate receptor 1,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: ELK-ELK4466.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human S1PR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human S1PR1. Next,...
Schlagworte: | S1P1, CD363, S1PR1, CHEDG1, S1P receptor 1, S1P receptor Edg-1, Sphingosine 1-phosphate receptor 1, Sphingosine... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: CAY10009109-1
W146 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (Ki = 77 nM). It is selective for S1P1 over S1P2, S1P3, and S1P5 receptors (Kis = >10 µM for all). W146 prevents ligand-induced receptor internalization in CHO cells and inhibits the phosphorylation of ERK1 and Akt when used at a concentration of 10 µM....
Schlagworte: | [3R-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate) |
Anwendung: | S1P1 receptor antagonist |
CAS | 909725-62-8 |
MW: | 456.4 D |
ab 101,00 €
Artikelnummer: Cay10010426-10
KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea...
Schlagworte: | Mocravimod (hydrochloride), 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol,... |
Anwendung: | S1P1 receptor agonist |
CAS | 509088-69-1 |
MW: | 480.4 D |
ab 68,00 €
Artikelnummer: Cay13240-1
Sphingosine-1-phosphate (S1P, Cay-62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1,...
Schlagworte: | (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate |
Anwendung: | Competitive S1P1 / S1P3 receptor antagonist |
CAS | 449173-19-7 |
MW: | 372.4 D |
ab 54,00 €
Artikelnummer: Cay10010992-1
Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of...
Schlagworte: | 3-(2-(3-hexylphenylamino)-2-oxoethylamino)propanoic acid |
Anwendung: | S1P1 antagonist |
CAS | 1345982-24-2 |
MW: | 306.4 D |
ab 115,00 €
Artikelnummer: Cay11975-5
Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2...
Schlagworte: | 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol |
Anwendung: | S1P receptor agonist |
CAS | 162359-55-9 |
MW: | 307.5 D |
ab 76,00 €
Artikelnummer: AG-CR1-0005-M001
Saturated analog of sphingosine 1-phosphate (1-SP1), Ligand for sphingosine 1-phophate (S1P/EDG) receptors, Negative control for intracellular effects of sphingosine 1-phosphate, Induces chemotaxis, Antifibrotic.
Schlagworte: | (2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P |
Anwendung: | Bioassays |
MW: | 381,5 D |
ab 105,00 €
Artikelnummer: Cay22500-500
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses...
Schlagworte: | C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate,... |
Anwendung: | Metabolic glycosphingolipid / sphingolipid intermediate, EDG1 antagonist |
CAS | 19794-97-9 |
MW: | 381.5 D |
ab 84,00 €
Lipid-based Drug Delivery-Tools
Artikelnummer: Cay9002921-1
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate (S1P, Cay-62570) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma...
Schlagworte: | C16 S1P, C16 Sphingosine-1-phosphate, S1P (d16:1), 2S-amino-1-(dihydrogen phosphate), 4E-hexadecene-1,3R-diol |
Anwendung: | S1PR1/S1PR2/S1PR3 ligand |
CAS | 709026-60-8 |
MW: | 351.4 D |
ab 270,00 €
Artikelnummer: Cay16925-1
Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 is important for vascular development and lymphocyte maturation, migration, and trafficking. CYM...
Schlagworte: | 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-ethanol |
Anwendung: | S1PR1 internalization, phosphorylation, ubiquitination agonist |
CAS | 1094042-01-9 |
MW: | 409.5 D |
ab 66,00 €
Artikelnummer: Cay10009110-500
W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist W146 (Cay-10009109). It only weakly binds to S1P1 (Ki = 4.6 µM for the human receptor). W140 has been used as a negative control in vitro and in vivo in the study of S1P1 signaling.Formal Name:...
Schlagworte: | [3S-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate) |
Anwendung: | S1P1 Antagonist Control |
CAS | 909725-64-0 |
MW: | 456.4 D |
ab 105,00 €