Lipoxygenin

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 (Cay-22030). It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-beta-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 (Cay-13122).Formal Name: 2',4,6-trimethoxy-alpha-2-naphthalenyl-[3,3'-bipyridine]-5-methanol. CAS Number: 2247911-68-6. Molecular Formula: C24H22N2O4. Formula Weight: 402.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL. lambdamax: 225 nm. SMILES: OC(C1=C(OC)C(C2=CC=CN=C2OC)=CN=C1OC)C3=CC=C(C=CC=C4)C4=C3. InChi Code: InChI=1S/C24H22N2O4/c1-28-22-19(18-9-6-12-25-23(18)29-2)14-26-24(30-3)20(22)21(27)17-11-10-15-7-4-5-8-16(15)13-17/h4-14,21,27H,1-3H3. InChi Key: OSVNGDATIGOCLA-UHFFFAOYSA-N.