Zu "K00461" wurden 126 Artikel gefunden!
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Zileuton
Artikelnummer: Cay10006967-50
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
| Schlagworte: | A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea |
| Anwendung: | 5-LO inhibitor |
| CAS | 111406-87-2 |
| MW: | 236.3 D |
ab 29,00 €
AKBA
Artikelnummer: TGM-T5S1569-100mg
Description: AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2. Target: Endogenous Metabolite, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Others. Smiles: CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C. References:...
| Schlagworte: | 3-O-Acetyl-11-keto-beta-boswellic acid, 3-O-Acetyl-11-keto-beta-boswellic acid, Acetyl-11-keto-beta-boswellic acid |
| Anwendung: | 5-lipoxygenase inhibitor |
| CAS | 67416-61-9 |
| MW: | 512.72 D |
ab 37,00 €
Piriprost
Artikelnummer: TGM-T68682-100mg
Description: Piriprost is a leukotriene inhibitor attenuates the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type I alveolar epithelium. Target: Others. Smiles:...
| Anwendung: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 79672-88-1 |
| MW: | 425.56 D |
ab 1.520,00 €
MK-886 sodium salt
Artikelnummer: TGM-T71309-10mg
Description: MK-886 sodium salt inhibits leukotriene biosynthesis in leukocytes. Target: Others
| Anwendung: | Leukotriene biosynthesis inhibitor |
| CAS | 118427-55-7 |
| MW: | 494.06 D |
ab 77,00 €
5-LOX-IN-2
Artikelnummer: TGM-T77528-100mg
Description: 5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 µM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research. Target: Apoptosis, Lipoxygenase. Smiles:...
| Anwendung: | 5-lipoxygenase inhibitor |
| CAS | 179691-97-5 |
| MW: | 284.31 D |
ab 52,00 €
Tepoxalin
Artikelnummer: TGM-T7724-100mg
Description: Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxygenase (COX) (IC50 = 4.6 microM), rat basophilic leukemia cell (RBL-1) lysate COX...
| Schlagworte: | RWJ-20485, ORF20485, RWJ20485, RWJ 20485, ORF 20485, ORF-20485 |
| Anwendung: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 103475-41-8 |
| MW: | 385.84 D |
ab 52,00 €
Tryptanthrin
Artikelnummer: TGM-T7786-100mg
Description: Tryptanthrin is a natural DNA gyrase inhibitor. Target: DNA gyrase. Smiles: O=C1N2C(C(=O)C=3C2=CC=CC3)=NC=4C1=CC=CC4. References: Liao X , Zhou X , Mak N K , et al. Tryptanthrin Inhibits Angiogenesis by Targeting the VEGFR2-Mediated ERK1/2 Signalling Pathway[J]. PLOS ONE, 2013, 8.
| Anwendung: | 5-lipoxygenase / cyclooxygenase-2 inhibitor |
| CAS | 13220-57-0 |
| MW: | 248.24 D |
ab 40,00 €
Benzydamine
Artikelnummer: TGM-T8807-100mg
Description: Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. Target: Others. Smiles: C(N1C=2C(C(OCCCN(C)C)=N1)=CC=CC2)C3=CC=CC=C3. References: N P Singh, J K Makkar, V...
| Anwendung: | Targets prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1] (PTGS1, COX1) |
| CAS | 642-72-8 |
| MW: | 309.41 D |
ab 49,00 €
Oxatomide
Artikelnummer: TGM-T19839-100mg
Description: Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2X7 receptor with an IC50 value of 0.95 µM.Oxatomide has an inhibitory effect on...
| Schlagworte: | Oxatomida |
| Anwendung: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 60607-34-3 |
| MW: | 426.55 D |
ab 33,00 €
Benoxaprofen
Artikelnummer: TGM-T19679-100mg
Description: Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug. Target: COX. Smiles: C(C(O)=O)(C)C=1C=C2C(OC(=N2)C3=CC=C(Cl)C=C3)=CC1. References: Chin KY, El-Kayat B, Milne A, Hart A. Melanoma diagnosed 27 years after a benoxaprofen-induced photosensitivity reaction. J Dermatol Case Rep. 2012 Mar...
| Schlagworte: | NSC 299582, Benoxaphen. Compound 90459, LY-90459 |
| Anwendung: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 51234-28-7 |
| MW: | 301.72 D |
ab 212,00 €
5-LOX inhibitor
Artikelnummer: TGM-T65427-100mg
Description: 5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor. Target: Lipoxygenase. Smiles: CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(O)cc2)c1=O. References: Pace JR,et al. Repurposing the...
| Schlagworte: | 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one |
| Anwendung: | 5-LOX inhibitor |
| CAS | 106461-41-0 |
| MW: | 393.48 D |
ab 49,00 €
Butein
Artikelnummer: TGM-T6427-100mg
Description: Butein (2',3,4,4'-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-kappaB and STAT3, and also can inhibit EGFR. Target: Apoptosis, Autophagy, EGFR, PDE, Others. Smiles: Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1....
| Schlagworte: | 2',3,4,4'-tetrahydroxy Chalcone |
| Anwendung: | Potent antioxidant, 5-lipoxygenase inhibitor |
| CAS | 487-52-5 |
| MW: | 272.25 D |
ab 37,00 €