Zu "K00461" wurden 131 Artikel gefunden!
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Oleacein
Artikelnummer: Cay40719-5
Oleacein is a secoiridoid polyphenol that has been found in O. europea and has diverse biological activities. It inhibits 5-lipoxygenase (5-LO, IC50 = 2 µM for the human enzyme). Oleacein (20 and 50 µM) reduces lipid accumulation and inhibits the transition into foam cells in human monocyte-derived macrophages. It...
| Schlagworte: | (3S,4E)-4-formyl-3-(2-oxoethyl)-4-hexenoic acid, 2-(3,4-dihydroxyphenyl) ethyl ester |
| Anwendung: | Bioactive secoiridoid polyphenol, weak 5-LO inhibitor |
| CAS | 149183-75-5 |
| MW: | 320.34 D |
483,00 €
Zileuton
Artikelnummer: Cay10006967-50
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
| Schlagworte: | A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea |
| Anwendung: | 5-LO inhibitor |
| CAS | 111406-87-2 |
| MW: | 236.3 D |
ab 33,00 €
MK-886 (sodium salt)
Artikelnummer: Cay10133-5
Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886...
| Schlagworte: | 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid,... |
| Anwendung: | Leukotriene biosynthesis inhibitor |
| CAS | 118427-55-7 |
| MW: | 494.1 D |
ab 49,00 €
5-Lipoxygenase (human, recombinant)
Artikelnummer: Cay60402-5
5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is composed of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation...
| Schlagworte: | LOG5, 5-LO, 5-LO, 5-lipoxygenase, 5-lipoxygenase, Arachidonate 5-lipoxygenase, Arachidonate 5-lipoxygenase,... |
| Anwendung: | Enzyme activity |
712,00 €
15(S)-HETrE
Artikelnummer: Cay36720-25
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 µM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.Formal Name:...
| Schlagworte: | 15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid |
| Anwendung: | 5-LO inhibitor |
| CAS | 92693-02-2 |
| MW: | 322.5 D |
ab 118,00 €
3-acetyl-11-keto-beta-Boswellic Acid
Artikelnummer: Cay11672-1
3-acetyl-11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner....
| Schlagworte: | 3-O-acetyl-11-keto-beta-Boswellic acid, AKBA, (3alpha,4beta)-3-(acetyloxy)-11-oxo-urs-12-en-23-oic acid |
| Anwendung: | 5-lipoxygenase inhibitor |
| CAS | 67416-61-9 |
| MW: | 512.7 D |
ab 56,00 €
AA-861
Artikelnummer: Cay13263-1
AA-861 is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 0.8 µM). It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4, Cay-20110, Cay-10007240) induced by A23187 (Cay-22030) with IC50 values of 0.03 and 0.08 µM,...
| Schlagworte: | A-61589, Docebenone, 2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione |
| Anwendung: | 5-LO inhibitor |
| CAS | 80809-81-0 |
| MW: | 326.4 D |
ab 247,00 €
Anti-5-Lipoxygenase
Artikelnummer: Cay160402-1
5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is comprised of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation...
| Schlagworte: | Anti-LOG5, Anti-5-LO, Anti-5-LO, Anti-5-lipoxygenase, Anti-5-lipoxygenase, Anti-Arachidonate 5-lipoxygenase,... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, murine, hamster, swine |
468,00 €
CJ-13610
Artikelnummer: Cay21764-1
CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 (Cay-11016) in vitro (IC50 = 70 nM). It inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM). CJ-13610 also inhibits 5-LO...
| Schlagworte: | tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide |
| Anwendung: | 5-lipoxygenase inhibitor |
| CAS | 179420-17-8 |
| MW: | 393.5 D |
ab 67,00 €
Myxochelin A
Artikelnummer: AG-CN2-0470-M001
Solid. Soluble in DMSO, ethanol, methanol, acetone, ethylacetate or chloroform. Insoluble in water or hexane. Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions,...
| Schlagworte: | (S)-N,N'-(6-Hydroxyhexane-1,5-diyl)bis(2,3-dihydroxybenzamide) |
| Anwendung: | 5-LO inhibitor, Iron-chelator, Anticancer, Antibiotic, Antibacterial, Antioxidant |
| CAS | 120243-02-9 |
| MW: | 404,4 D |
ab 99,00 €
Esculetin
Artikelnummer: Cay19286-1
Esculetin is a coumarin that has been found in Euphorbia and has diverse biological activities. It inhibits 5-lipoxygenase (5-LO) and 12-LO (IC50s = 4 and 2.5 µM, respectively), as well as the histone demethylase jumonji AT-rich interactive domain 1B (JARID1B, IC50 = 4.6 µM). Esculetin is active against B. cereus,...
| Schlagworte: | 6,7-Dihydroxycoumarin, Aesculetin, Cichorigenin, NSC 26427, 6,7-dihydroxy-2H-1-benzopyran-2-one |
| Anwendung: | Iron chelator, iron-containing enzyme inhibitor, apoptosis inducer, antioxidant |
| CAS | 305-01-1 |
| MW: | 178.1 D |
ab 49,00 €
15(S)-HEDE
Artikelnummer: Cay37720-50
15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 µM.Formal Name: 15S-hydroxy-11Z,13E-eicosadienoic acid. CAS Number: 92693-04-4. Molecular Formula: C20H36O3. Formula Weight: 324.5. Purity: >98%. Formulation: (Request formulation...
| Schlagworte: | 15S-hydroxy-11Z,13E-eicosadienoic acid |
| Anwendung: | 5-LO inhibitor |
| CAS | 92693-04-4 |
| MW: | 324.5 D |
ab 174,00 €