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Zu "K00461" wurden 91 Artikel gefunden!
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Artikelnummer: Cay38973-10
Stearda is an endogenous fatty acid amide composed of the catecholamine dopamine (Cay-36532, Cay-21992) conjugated to the long-chain saturated fatty acid stearic acid (Cay-10011298). It is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 16 nM). Stearda is cytotoxic to K562 chronic myeloid leukemia cells, HOS...
Schlagworte: | N-octadecanoyl Dopamine, N-Stearoyl Dopamine, N-[2-(3,4-dihydroxyphenyl)ethyl]-octadecanamide |
Anwendung: | Endogenous fatty acid amide, arachidonate 5-lipoxygenase inhibitor |
CAS | 105955-10-0 |
MW: | 419.6 D |
ab 88,00 €
Artikelnummer: ELK-ELK3188.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ALOX5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ALOX5. Next,...
Schlagworte: | 5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase, Polyunsaturated fatty acid 5-lipoxygenase |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: ELK-ELK1892.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ALOX5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ALOX5. Next,...
Schlagworte: | 5-LO, LOG5, 5-lipoxygenase, Arachidonate 5-lipoxygenase, Polyunsaturated fatty acid 5-lipoxygenase |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK5763.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat ALOX5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat ALOX5. Next,...
Schlagworte: | 5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase, Polyunsaturated fatty acid 5-lipoxygenase |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: Cay10006967-50
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
Schlagworte: | A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea |
Anwendung: | 5-LO inhibitor |
CAS | 111406-87-2 |
MW: | 236.3 D |
ab 28,00 €
Artikelnummer: Cay10858-10
Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 15 nM). It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Cay-11016) in isolated human polymorphonuclear...
Schlagworte: | CDC, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 3-phenyl-2-propen-1-yl ester |
Anwendung: | 5-lipoxygenase inhibitor |
CAS | 132465-11-3 |
MW: | 321.3 D |
ab 47,00 €
Artikelnummer: Cay10133-5
Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886...
Schlagworte: | 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid,... |
Anwendung: | Leukotriene biosynthesis inhibitor |
CAS | 118427-55-7 |
MW: | 494.1 D |
ab 43,00 €
Artikelnummer: Cay60402-5
5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is composed of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation...
Schlagworte: | LOG5, 5-LO, 5-LO, 5-lipoxygenase, 5-lipoxygenase, Arachidonate 5-lipoxygenase, Arachidonate 5-lipoxygenase,... |
Anwendung: | Enzyme activity |
642,00 €
Artikelnummer: Cay11672-1
3-acetyl-11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner....
Schlagworte: | 3-O-acetyl-11-keto-beta-Boswellic acid, AKBA, (3alpha,4beta)-3-(acetyloxy)-11-oxo-urs-12-en-23-oic acid |
Anwendung: | 5-lipoxygenase inhibitor |
CAS | 67416-61-9 |
MW: | 512.7 D |
ab 50,00 €
Artikelnummer: Cay36720-25
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 µM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.Formal Name:...
Schlagworte: | 15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid |
Anwendung: | 5-LO inhibitor |
CAS | 92693-02-2 |
MW: | 322.5 D |
ab 106,00 €
Artikelnummer: Cay13263-1
AA-861 is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 0.8 µM). It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4, Cay-20110, Cay-10007240) induced by A23187 (Cay-22030) with IC50 values of 0.03 and 0.08 µM,...
Schlagworte: | A-61589, Docebenone, 2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione |
Anwendung: | 5-LO inhibitor |
CAS | 80809-81-0 |
MW: | 326.4 D |
ab 222,00 €
Artikelnummer: Cay21764-1
CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 (Cay-11016) in vitro (IC50 = 70 nM). It inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM). CJ-13610 also inhibits 5-LO...
Schlagworte: | tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide |
Anwendung: | 5-lipoxygenase inhibitor |
CAS | 179420-17-8 |
MW: | 393.5 D |
ab 60,00 €