(±)-Ibuprofen

(±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively). In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg). It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.Formal Name: (±)-alpha-methyl-4-(2-methylpropyl)-benzeneacetic acid. CAS Number: 15687-27-1. Synonyms: DL-Ibuprofen, NSC 256857, U-18753. Molecular Formula: C13H18O2. Formula Weight: 206.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 45 mg/ml, DMSO: 50 mg/ml, Ethanol: 60 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: CC(C)Cc1ccc(cc1)C(C)C(=O)O. InChi Code: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15). InChi Key: HEFNNWSXXWATRW-UHFFFAOYSA-N.