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COX Fluorescent Inhibitor Screening Assay Kit
COX Fluorescent Inhibitor Screening Assay Kit

Artikelnummer: Cay700100-192

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the...
Schlagworte: Cyclooxygenase Fluorescent Inhibitor Screening Assay Kit
Anwendung: COX inhibitor screening
719,00 €
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NEU
Flufenamic Acid-d4
Flufenamic Acid-d4

Artikelnummer: Cay33272-1

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid (Cay-21447) by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits...
Schlagworte: FFA-d4, Fluphenamic Acid-d4, 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid-d4
Anwendung: GC-MS, LC-MS internal standard, Quantification, NSAID, COX inhibitor
CAS 1185071-99-1
MW: 285.3 D
ab 162,00 €
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NEU
Oxaprozin-d5
Oxaprozin-d5

Artikelnummer: Cay33279-1

Oxaprozin-d5 is intended for use as an internal standard for the quantification of oxaprozin (Cay-15476) by GC- or LC-MS. Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 µM for human COX-1 and COX-2, respectively). It decreases acetic acid-induced writhing times and...
Schlagworte: 4-phenyl-5-(phenyl-d5)-2-oxazolepropanoic acid
Anwendung: GC-MS, LC-MS internal standard, Quantification, NSAID, COX inhibitor
MW: 298.4 D
ab 107,00 €
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NEU
Pamicogrel
Pamicogrel

Artikelnummer: Cay33514-250

Pamicogrel is a COX inhibitor and an antiplatelet agent. It inhibits platelet aggregation induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) or collagen in washed isolated rabbit platelets (IC50s = 1.5 and 0.43 µM, respectively). Pamicogrel (1 mg/kg) reduces thrombus weight in a guinea pig model of...
Schlagworte: KBT-3022, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-1H-pyrrole-1-acetic acid, ethyl ester
Anwendung: Platelet aggregation inhibitor, COX inhibitor
CAS 101001-34-7
MW: 448.5 D
ab 37,00 €
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NEU
Nimesulide-d5
Nimesulide-d5

Artikelnummer: Cay33813-1

Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide (Cay-70640) by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1...
Schlagworte: R805-d5, N-(4-nitro-2-(phenoxy-d5)phenyl)methanesulfonamide
Anwendung: GC-MS, LC-MS internal standard, Quantification, COX-2 inhibitor
CAS 1330180-22-7
MW: 313.3 D
ab 87,00 €
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NEU
GW 406381
GW 406381

Artikelnummer: Cay33895-1

GW 406381 is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 3 nM). It is selective for COX-2 over COX-1 (IC50 = >84.2 µM). GW 406381 (5 mg/kg) reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain.Formal Name:...
Schlagworte: GW406381X, 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine
Anwendung: NSAID, COX-2 inhibitor
CAS 221148-46-5
MW: 393.5 D
ab 32,00 €
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Anti-COX-2 (Clone CX229)
Anti-COX-2 (Clone CX229)

Artikelnummer: Cay160112-1

Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2, Cay-17010), and...
Schlagworte: Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2
Anwendung: IHC, WB
Reaktivität: Human, Ovine, Monkey
324,00 €
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APHS
APHS

Artikelnummer: Cay70330-1

APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC50 values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of...
Schlagworte: 2-(2-heptynylthio)-phenol acetate
Anwendung: Potent COX-1 / COX-2 inhibitor
CAS 209125-28-0
MW: 262.4 D
ab 10,00 €
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Alclofenac
Alclofenac

Artikelnummer: Cay29877-10

Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and anti-pyretic properties. It inhibits contractions induced by serotonin (5-HT) in isolated guinea pig ileum by 28% when used at a concentration of 200 µg/ml. Alclofenac (480 mg/kg per day) decreases implant neutrophil...
Schlagworte: 3-chloro-4-(2-propen-1-yloxy)-benzeneacetic acid
Anwendung: Analgesic, antiinflammatory, antipyretic NSAID
CAS 22131-79-9
MW: 226.7 D
ab 57,00 €
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Lornoxicam-d4
Lornoxicam-d4

Artikelnummer: Cay33275-1

Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam (Cay-70220) by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2, Cay-19030) from...
Schlagworte: Chlortenoxicam-d4, Ro 13-9297-d4,...
Anwendung: GC-MS, LC-MS, Internal standard, Quantification, COX-1 / COX-2 inhibitor
CAS 1216527-48-8
MW: 375.8 D
ab 62,00 €
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Sulindac-d3
Sulindac-d3

Artikelnummer: Cay33381-1

Sulindac-d3 is intended for use as an internal standard for the quantification of sulindac (Cay-10004386) by GC- or LC-MS. Sulindac is a non-steroidal anti-inflammatory drug (NSAID), selective COX-2 inhibitor (IC50s = 0.79 and >1,000 µM for COX-2 and COX-1, respectively), and prodrug form of sulindac sulfide...
Schlagworte: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl-d3)phenyl]methylene]-1H-indene-3-acetic acid
Anwendung: GC-MS, LC-MS, Internal standard, Quantification, COX inhibitor
MW: 359.4 D
ab 124,00 €
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Piroxicam-d3
Piroxicam-d3

Artikelnummer: Cay33248-5

Piroxicam-d3 is intended for use as an internal standard for the quantification of piroxicam (Cay-13368) by GC- or LC-MS. Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2, Cay-19030) from...
Schlagworte: 1,1-dioxide-4-hydroxy-2-(methyl-d3)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide
Anwendung: Internal standard, GC-MS, LC-MS, Quantification, COX inhibitor, NSAID
CAS 942047-64-5
MW: 334.4 D
ab 169,00 €
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