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COX Fluorescent Inhibitor Screening Assay Kit
COX Fluorescent Inhibitor Screening Assay Kit

Artikelnummer: Cay700100-192

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the...
Schlagworte: COX2, COX-2, PTGS2, PGHS-2, PHS II, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2 synthase 2,...
Anwendung: COX inhibitor screening
719,00 €
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Anti-COX-2 (mouse) (aa 570-598)
Anti-COX-2 (mouse) (aa 570-598)

Artikelnummer: Cay160106-500

COX catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of COX by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothosis that the...
Schlagworte: Anti-Ptgs2, Anti-COX-2, Anti-PES-2, Anti-PHS II, Anti-PGHS-2, Anti-Gripghs, EC=1.14.99.1, Anti-TIS10 protein, Anti-PGH...
Anwendung: WB, IHC, ICC
Reaktivität: Ovine, Human, Mouse, Rabbit, Monkey, Guinea Pig, Rat
324,00 €
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Anti-COX-2 (Clone CX229)
Anti-COX-2 (Clone CX229)

Artikelnummer: Cay160112-1

Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines...
Schlagworte: Anti-COX2, Anti-PTGS2, Anti-COX-2, Anti-PHS II, Anti-PGHS-2, EC=1.14.99.1, Anti-PGH synthase 2, Anti-Cyclooxygenase-2,...
Anwendung: IHC, WB
Reaktivität: Human, Ovine, Monkey
324,00 €
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COX-2 (human recombinant)
COX-2 (human recombinant)

Artikelnummer: Cay60122-5

Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid (Cay-90010) to PGH2 (Cay-17020). Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and...
Schlagworte: COX2, PTGS2, COX-2, PHS II, PGHS-2, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2 synthase 2,...
Anwendung: Enzyme activity
844,00 €
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COX-2 (human) Inhibitor Screening Assay Kit
COX-2 (human) Inhibitor Screening Assay Kit

Artikelnummer: Cay701080-96

COX-1 and COX-2 catalyze the production of the prostaglandin (PG) and thromboxane precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-2 (human recombinant) Inhibitor Screening Assay measures PGF2alpha that is produced by SnCl2 reduction of...
Schlagworte: Cyclooxygenase 2, COX2, COX-2, PTGS2, PHS II, PGHS-2, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2...
Anwendung: Inhibitor screening
469,00 €
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Diclofenac (sodium salt)
Diclofenac (sodium salt)

Artikelnummer: Cay70680-5000

Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.
Schlagworte: Benfofen, Ecofenac, Voltaren, 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, monosodium salt
Anwendung: COX inhibitor
CAS 15307-79-6
MW: 318.1 D
ab 30,00 €
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Celecoxib
Celecoxib

Artikelnummer: LKT-C1644.1

Celecoxib is a selective COX 2 inhibitor.
Anwendung: COX-2 inhibitor
CAS 169590-42-5
MW: 381,37 D
ab 118,00 €
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CAY10404
CAY10404

Artikelnummer: Cay70210-1

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans. CAY10404 is one of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI, SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM,...
Schlagworte: 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole
Anwendung: COX-2 inhibitor
CAS 340267-36-9
MW: 367.4 D
ab 23,00 €
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NS-398
NS-398

Artikelnummer: Cay70590-5

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 µM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 µM, respectively.
Schlagworte: N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
Anwendung: COX-2 inhibitor
CAS 123653-11-2
MW: 314.4 D
ab 48,00 €
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Aspirin
Aspirin

Artikelnummer: Cay70260-50

Aspirin is a non-selective, irreversible COX inhibitor. The IC50 values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.
Schlagworte: Acetylsalicylic Acid, 2-(acetyloxy)-benzoic acid
Anwendung: COX inhibitor
CAS 50-78-2
MW: 180.2 D
ab 13,00 €
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Valdecoxib
Valdecoxib

Artikelnummer: Cay10006120-5

Valdecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits COX-2, exhibiting IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay. The COX-2 selectivity ratio of 30 for valdecoxib in this assay is similar to the ratio of 35 observed for rofecoxib...
Schlagworte: Bextra, 4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide
Anwendung: COX-2 inhibitor
CAS 181695-72-7
MW: 314.4 D
ab 73,00 €
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Celecoxib
Celecoxib

Artikelnummer: Cay10008672-100

Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 µM for COX-1 and COX-2, respectively). In vivo, celecoxib (0.3 ml of a 0.4% solution) administered intra-articularly reduces production of IL-1beta, TNF-alpha, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis. It...
Schlagworte: Celebra, Celebrex(TM), Onsenal, SC-58635, Xilebao, YM-177,...
Anwendung: COX-2 inhibitor
CAS 169590-42-5
MW: 381.4 D
ab 44,00 €
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