Flufenamic Acid-d4

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid (Cay-21447) by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-alpha-induced increases in COX-2 levels and NF-kappaB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP (fMLF, Cay-21495) or A23187 (Cay-11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively. Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1). It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.Formal Name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid-d4. CAS Number: 1185071-99-1. Synonyms: FFA-d4, Fluphenamic Acid-d4. Molecular Formula: C14H6D4F3NO2. Formula Weight: 285.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: OC(C(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=CC(C(F)(F)F)=CC=C2)=OOC(C(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=CC(C(F)(F)F)=CC=C2)=O. InChi Code: InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)/i1D,2D,6D,7D. InChi Key: LPEPZBJOKDYZAD-ZEJCXXMWSA-N.