11-deoxy Corticosterone

11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland. It is a metabolite of progesterone (Cay-15876) and precursor to aldosterone (Cay-15273) and corticosterone (Cay-16063). DOC is metabolized to the neuroactive compound (3alpha,5alpha)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats. Injections of naloxone (Cay-15594, Cay-ISO60191) and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys. DOC levels are increased 3.4-fold in obese and diabetic mice.Formal Name: 21-hydroxy-pregn-4-ene-3,20-dione. CAS Number: 64-85-7. Synonyms: DOC, NSC 11319, 21-hydroxy Progesterone. Molecular Formula: C21H30O3. Formula Weight: 330.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 240 nm. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(CO)=O)=C1. InChi Code: InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1. InChi Key: ZESRJSPZRDMNHY-YFWFAHHUSA-N.