1-Linoleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

1-Linoleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) (1-linoleoyl LPA) is an agonist of the LPA2 receptor and a glycerophospholipid containing linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) at the sn-1 position. It is the most abundant LPA in mouse and human plasma. 1-Linoleoyl LPA selectively increases intracellular calcium levels in LPA2 receptor-expressing Sf9 cells (EC50 = ~10 nM) over LPA1 and LPA3 receptor-expressing Sf9 cells (EC50s = ~200 and ~80 nM, respectively). Serum levels of 1-linoleoyl LPA are increased in mice bearing NCTC clone 2472 tumors. Plasma 1-linoleoyl LPA levels are decreased in patients with primary progressive, but not relapsing-remitting, multiple sclerosis and are negatively correlated with neurological deficit severity.Formal Name: 9Z,12Z-octadecadienoic acid, 2R-hydroxy-3-(phosphonooxy)propyl ester, sodium salt. CAS Number: 72777-86-7. Synonyms: 1-Linoleoyl LPA, 1-Linoleoyl Lysophosphatidic Acid, LPA 18:2, 18:2 LPA, 1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate, PA(18:2/0:0). Molecular Formula: C21H39O7P . XNa. Formula Weight: 434.5. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(CCCCCCC/C=C\C/C=C\CCCCC)OC[C@@H](O)COP(O)(O)=O.[Na]. InChi Code: InChI=1S/C21H39O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26,/h6-7,9-10,20,22H,2-5,8,11-19H2,1H3,(H2,24,25,26),/b7-6-,10-9-,/t20-,/m1./s1. InChi Key: CLFDTXJHXXYCFR-OOCWZJBTSA-N.