XY1

Protein arginine N-methyltransferase 3 (PRMT3, Cay-11642) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 (Cay-17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea. CAS Number: 1624117-53-8. Molecular Formula: C17H19N3O2. Formula Weight: 297.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 245 nm. SMILES: O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=CC=C3C=C2. InChi Code: InChI=1S/C17H19N3O2/c21-16(20-9-3-4-10-20)12-18-17(22)19-15-8-7-13-5-1-2-6-14(13)11-15/h1-2,5-8,11H,3-4,9-10,12H2,(H2,18,19,22). InChi Key: GSQHGSRPQHBTTP-UHFFFAOYSA-N.