VUF 5574

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine (Cay-21232) in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 µg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.Formal Name: N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-urea. CAS Number: 280570-45-8. Molecular Formula: C21H17N5O2. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 4 mM. SMILES: O=C(NC1=C(OC)C=CC=C1)NC2=NC(C3=CN=CC=C3)=NC4=C2C=CC=C4. InChi Code: InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27). InChi Key: YRAFEJSZTVWUMD-UHFFFAOYSA-N.