VU0661013

VU0661013 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = 97 pM). It is selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively). VU0661013 inhibits cell growth in a panel of acute myeloid leukemia (AML) cell lines (GI50s = 0.16-7.62 µM). It decreases blood, bone marrow, and spleen leukemic burden, reduces splenomegaly, and increases survival in a MV4-11 disseminated AML mouse xenograft model when administered at a dose of 75 mg/kg. VU0661013 also selectively inhibits glutathione peroxidase 4 (GPX4, IC50 = 8.4 µM) over GPX1, GPX2, glutathione reductase (GR), and thioredoxin reductase 1 (TrxR1).Formal Name: 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-1H-indole-5-carboxylic acid. CAS Number: 2131184-57-9. Molecular Formula: C39H39Cl2N5O4. Formula Weight: 712.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: C[C@H]1N2C3=C(C4=C(C)N(C)N=C4C)C(Cl)=CC=C3C(CCCOC5=CC(C)=C(C(C)=C5)Cl)=C2C(N(C(C6=C7)=CN(C)C6=CC=C7C(O)=O)C1)=O. InChi Code: InChI=1S/C39H39Cl2N5O4/c1-20-15-26(16-21(2)35(20)41)50-14-8-9-27-28-11-12-30(40)34(33-23(4)42-44(7)24(33)5)36(28)46-22(3)18-45(38(47)37(27)46)32-19-43(6)31-13-10-25(39(48)49)17-29(31)32/h10-13,15-17,19,22H,8-9,14,18H2,1-7H3,(H,48,49)/t22-/m1/s1. InChi Key: BSAYHBZFNXDOIJ-JOCHJYFZSA-N.