Zu "K02539" wurden 121 Artikel gefunden!
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Anti-Mcl-1 (Myeloid Cell Leukemia-1)
Artikelnummer: 600-401-394
Protein function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [The UniProt Consortium]
| Schlagworte: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
733,00 €
Anti-MCL, Rat, mAb WEN42
Artikelnummer: HYC-HM3042-100UG
For immunohistochemistry, flow cytometry, immunoprecipitation and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
| Schlagworte: | Anti-Mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| Anwendung: | FC, IHC-F, FA, IP, WB |
| Spezies-Reaktivität: | rat |
ab 139,00 €
ABBV-467
Artikelnummer: Cay44289-1
ABBV-467 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = 642, >376, >247, and >402 nM, respectively). ABBV-467 reduces the viability of AMO1, NCI H929, and MV4-11 myeloma cells (EC50s = 0. 0. and 3. nM, respectively). In vivo, ABBV-467 (3. 6. and 12. mg/kg) reduces tumor growth in an AMO1 mouse xenograft...
| Schlagworte: | (7R,16R)-19,23-dichloro-10-[[2-[4-[(2R)-1,4-dioxan-2-ylmethoxy]phenyl]-4-pyrimidinyl]methoxy]-1-(4-fluorophenyl)-7,8,15,16... |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 2287186-66-5 |
| MW: | 1037.98 D |
364,00 €
MCL1, His-Tag
Artikelnummer: BPS-40742
Human MCL1, also known as Induced myeloid leukemia cell differentiation protein and BCL2L3, GenBank Accession No. NM_021960, a.a. 2-327, with N-terminal His-tag, expressed in an E. coli expression system.
| Schlagworte: | MCL1, BCL2L3, Bcl2-L-3, mcl1/EAT, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Induced myeloid leukemia cell... |
| Anwendung: | Apoptosis studies, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 36 kD |
528,00 €
Anti-Mcl-1 Monoclonal Antibody
Artikelnummer: E-AN200070P.100
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 0) promote...
| Schlagworte: | MCL1, BCL2L3, Bcl2-L-3, mcl1/EAT, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Induced myeloid leukemia cell... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
MCL-1 Peptide Ligand
Artikelnummer: BPS-79507
MCL-1 Peptide Ligand is useful as a substrate for screening services and optimized for use with the following TR-FRET assay kits: * MCL-1 TR-FRET Assay kit (BPS-79506) * MCL-1 TR-FRET Assay kit (Mouse) (BPS-79928)
| Anwendung: | Substrate, screening, TR-FRET |
| MW: | 3162 D |
446,00 €
MCL-1 TR-FRET Assay Kit
Artikelnummer: BPS-79506
The MCL-1 TR-FRET Assay Kit is designed to measure the inhibition of MCL-1 binding to its ligand in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and...
| Schlagworte: | mcl1, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.365,00 €
MCL-1 TR-FRET Assay Kit (Mouse)
Artikelnummer: BPS-79928
The Mouse MCL-1 TR-FRET Assay Kit is designed to measure the inhibition of mouse MCL-1 binding to its ligand in a homogeneous 384 reaction format. This TR-FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is...
| Schlagworte: | MCL1 assay kit, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | mouse |
1.365,00 €
MCL-1 TR-FRET Assay Kit (Rat)
Artikelnummer: BPS-78804
The Induced myeloid leukemia cell differentiation protein (MCL-1) TR-FRET Assay Kit (Rat) is designed to measure the inhibition of rat MCL-1 binding to its ligand in a homogeneous 384-well format. This TR-FRET based assay requires no time-consuming washing steps, making it especially suitable for high throughput...
| Schlagworte: | Mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, |
| Anwendung: | Drug discovery, HTS |
| Spezies-Reaktivität: | rat |
1.365,00 €
Anti-Mcl-1
Artikelnummer: 600-401-394S
This affinity-purified antibody was prepared from monospecific antiserum by immunoaffinity chromatography using synthetic peptide coupled to agarose beads followed by cross adsorption to remove any unwanted reactivity. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. No...
| Schlagworte: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
180,00 €
S63845
Artikelnummer: Cay21131-5
S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1, Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis. S63845 acts synergistically with trametinib (Cay-16292), lapatinib...
| Schlagworte: | alpha(R)-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimi... |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 1799633-27-4 |
| MW: | 829.3 D |
ab 128,00 €
![3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid](https://www.biomol.com/media/image/6d/c7/de/Cay22948-100_200x200.png "3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid")
3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
Artikelnummer: Cay22948-250
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 µM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA)...
| Schlagworte: | 3,6-dichloro-benzo[b]thiophene-2-carboxylic acid |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 34576-94-8 |
| MW: | 247.1 D |
ab 49,00 €