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Zu "K02539" wurden 91 Artikel gefunden!
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Artikelnummer: 600-401-394
Protein function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [The UniProt Consortium]
Schlagworte: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse |
684,00 €
Artikelnummer: BPS-101299
Recombinant rat MCL1 (myeloid cell leukemia sequence 1) encompassing amino acids 2-307. This construct contains a N-terminal His-Tag (6xHis). The protein was affinity purified.
Schlagworte: | Mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, MCL1 (His-2-307) |
Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Exprimiert in: | E.coli |
Ursprungsart: | rat |
MW: | 34 kD |
518,00 €
-10 %
Rabattaktion
Artikelnummer: ELK-ELK7001.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MCL1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MCL1. Next,...
Schlagworte: | Mcl1, Bcl-2-related protein EAT/mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
365,00 €
ab 328,50 €
Artikelnummer: Cay39524-1
VU0661013 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = 97 pM). It is selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively). VU0661013 inhibits cell growth in a panel of acute myeloid leukemia (AML) cell lines (GI50s = 0.16-7.62 µM). It decreases blood, bone marrow, and spleen...
Schlagworte: | 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl... |
Anwendung: | Mcl-1 inhibitor |
CAS | 2131184-57-9 |
MW: | 712.7 D |
ab 133,00 €
Artikelnummer: ARG43908.50
Protein function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269, PubMed:10766760,...
Schlagworte: | Anti-MCL1, Anti-BCL2L3, Anti-Bcl2-L-3, Anti-mcl1/EAT, Anti-Bcl2-L-3, Anti-mcl1/EAT, Anti-Bcl-2-like protein 3,... |
Anwendung: | ELISA, FC, ICC, IF, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, rat |
520,00 €
Artikelnummer: BPS-79507
MCL-1 Peptide Ligand is useful as a substrate for screening services and optimized for use with the following TR-FRET assay kits: * MCL-1 TR-FRET Assay kit (BPS-79506) * MCL-1 TR-FRET Assay kit (Mouse) (BPS-79928)
Anwendung: | Substrate, screening, TR-FRET |
MW: | 3162 D |
289,00 €
Artikelnummer: BPS-79506
The MCL-1 TR-FRET Assay Kit is designed to measure the inhibition of MCL-1 binding to its ligand in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and...
Schlagworte: | mcl1, |
Anwendung: | Drug discovery, HTS |
Spezies-Reaktivität: | human |
1.274,00 €
Artikelnummer: BPS-79928
The Mouse MCL-1 TR-FRET Assay Kit is designed to measure the inhibition of mouse MCL-1 binding to its ligand in a homogeneous 384 reaction format. This TR-FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is...
Schlagworte: | MCL1 assay kit, |
Anwendung: | Drug discovery, HTS |
Spezies-Reaktivität: | mouse |
1.274,00 €
Artikelnummer: BPS-78804
The Induced myeloid leukemia cell differentiation protein (MCL-1) TR-FRET Assay Kit (Rat) is designed to measure the inhibition of rat MCL-1 binding to its ligand in a homogeneous 384-well format. This TR-FRET based assay requires no time-consuming washing steps, making it especially suitable for high throughput...
Schlagworte: | Mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, |
Anwendung: | Drug discovery, HTS |
Spezies-Reaktivität: | rat |
1.274,00 €
Artikelnummer: 600-401-394S
This affinity-purified antibody was prepared from monospecific antiserum by immunoaffinity chromatography using synthetic peptide coupled to agarose beads followed by cross adsorption to remove any unwanted reactivity. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. No...
Schlagworte: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse |
180,00 €
Artikelnummer: Cay21131-5
S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1, Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis. S63845 acts synergistically with trametinib (Cay-16292), lapatinib...
Schlagworte: | alpha(R)-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimi... |
Anwendung: | Mcl-1 inhibitor |
CAS | 1799633-27-4 |
MW: | 829.3 D |
ab 115,00 €
Artikelnummer: Cay22948-250
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 µM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA)...
Schlagworte: | 3,6-dichloro-benzo[b]thiophene-2-carboxylic acid |
Anwendung: | Mcl-1 inhibitor |
CAS | 34576-94-8 |
MW: | 247.1 D |
ab 43,00 €