Zu "K02539" wurden 111 Artikel gefunden!
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Anti-Mcl-1 (Myeloid Cell Leukemia-1)
Artikelnummer: 600-401-394
Protein function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [The UniProt Consortium]
| Schlagworte: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
719,00 €
MCL1, His-Tag
Artikelnummer: BPS-40742
Human MCL1, also known as Induced myeloid leukemia cell differentiation protein and BCL2L3, GenBank Accession No. NM_021960, a.a. 2-327, with N-terminal His-tag, expressed in an E. coli expression system.
| Schlagworte: | MCL1, BCL2L3, Bcl2-L-3, mcl1/EAT, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Induced myeloid leukemia cell... |
| Anwendung: | Apoptosis studies, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 36 kD |
528,00 €
Mcl-1 inhibitor 3
Artikelnummer: TGM-T11972-25mg
Description: Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM, IC50=19 nM in an OPM-2 cell viability assay). Target: BCL. Smiles:...
| Anwendung: | Mcl-1 inhibitor |
| CAS | 2376774-73-9 |
| MW: | 820.39 D |
1.520,00 €
MIM1
Artikelnummer: TGM-T12041-10mg
Description: MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor. Target: BCL. Smiles: Cc1cs\c(=N\C2CCCCC2)n1\N=C\c1ccc(O)c(O)c1O. References: Vidomanova E, et al. Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines....
| Schlagworte: | Inhibitor of Mcl-1 |
| Anwendung: | Selective MCL-1 ligand |
| CAS | 509102-00-5 |
| MW: | 347.43 D |
ab 31,00 €
MIK665
Artikelnummer: TGM-T12629L-100mg
Description: MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia. Target: BCL. Smiles: COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1. References: Zoltán SZLÁVIK, et al. New hydroxyester derivatives, a process for their preparation and...
| Schlagworte: | S-64315 |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 1799631-75-6 |
| MW: | 875.41 D |
ab 134,00 €
VU0661013
Artikelnummer: TGM-T17247-100mg
Description: VU0661013 is an effective and selective inhibitor of MCL-1. Target: BCL. Smiles: C[C@@H]1CN(c2cn(C)c3ccc(cc23)C(O)=O)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n12. References: Haley E. Ramsey, et al. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute...
| Schlagworte: | VU661013 |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 2131184-57-9 |
| MW: | 712.66 D |
ab 63,00 €
BT2
Artikelnummer: TGM-T14834-100mg
Description: BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 µM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain alpha-ketoacid dehydrogenase...
| Anwendung: | Mcl-1 inhibitor |
| CAS | 34576-94-8 |
| MW: | 247.1 D |
ab 40,00 €
Tapotoclax
Artikelnummer: TGM-T14213-1mg
Description: AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM). Target: BCL. Smiles: [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1. References: Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in...
| Schlagworte: | AMG-176 |
| Anwendung: | Targets myeloid leukemia cell differntiation protein MCL-1 (MCL1) |
| CAS | 1883727-34-1 |
| MW: | 613.21 D |
592,00 €
Homoharringtonine
Artikelnummer: TGM-T3380-100mg
Description: Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity. Target: STAT. Smiles:...
| Schlagworte: | Myelostat, HHT, Omacetaxine mepesuccinate, Ceflatonin |
| Anwendung: | Targets G1/S-specific cyclin-D1 (CCND1) |
| CAS | 26833-87-4 |
| MW: | 545.62 D |
ab 49,00 €
A-1210477
Artikelnummer: TGM-T2632-2mg
Description: A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM). Target: Apoptosis, BCL. Smiles: C(CN1CCOCC1)N2C3=C(C=CC=C3C(CCCOC=4C5=C(C=CC4)C=CC=C5)=C2C(O)=O)C6=C(COC7=CC=C(C=C7)N8CCN(S(N(C)C)(=O)=O)CC8)N(C)N=C6C. References: Leverson JD, et al. Cell Death Dis. 2015,...
| Anwendung: | Mcl-1 inhibitor |
| CAS | 1668553-26-1 |
| MW: | 850.04 D |
ab 34,00 €
ML311
Artikelnummer: TGM-T5108-100mg
Description: ML311 is a selective inhibitor of the Mcl-1/Bim interaction. Target: BCL. Smiles: CCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O. References: Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying...
| Anwendung: | Mcl-1 inhibitor |
| CAS | 315698-17-0 |
| MW: | 415.45 D |
ab 37,00 €
UMI-77
Artikelnummer: TGM-T6034-100mg
Description: UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family. Target: BCL. Smiles: OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O. References: Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575.
| Schlagworte: | UMI 77, UMI77 |
| Anwendung: | Mcl-1 inhibitor |
| CAS | 518303-20-3 |
| MW: | 468.34 D |
ab 37,00 €