UF010

UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 µM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 µM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G1/S phase of the cell cycle.Formal Name: 4-bromo-benzoic acid, 2-butylhydrazide. CAS Number: 537672-41-6. Molecular Formula: C11H15BrN2O. Formula Weight: 271.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH7.2) (1:7): 0.1 mg/ml. lambdamax: 240 nm. SMILES: BrC1=CC=C(C(NNCCCC)=O)C=C1. InChi Code: InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15). InChi Key: BVQCFCYPFJOOAV-UHFFFAOYSA-N.