Zu "K11405" wurden 72 Artikel gefunden!
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HDAC8 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-04631-100ug
Description: HDAC8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. The accession number is Q9BY41.
| Schlagworte: | HDAC8 , Protein deacetylase HDAC8 , Protein decrotonylase HDAC8 , Histone deacetylase 8 , HDACL1 , HD8 |
| MW: | 57.8 kD |
ab 82,00 €
TM-2-51
Artikelnummer: Cay45129-1
An activator of HDAC8, inhibits growth of SH-SY5Y neuroblastoma cells expressing wild-type p53 at 10, 40, and 80 µM, induces apoptosis at 80 µM in the same cells, inhibits growth and migration in U2OS and 143B osteosarcoma cells, inhibits tumor growth in a 143B mouse xenograft model at 10 mg/kg. SMILES:...
| Schlagworte: | NSC 5817, N-[(phenylamino)thioxomethyl]-benzamide |
| Anwendung: | HDAC8 activator |
| CAS | 4921-82-8 |
| MW: | 256.32 D |
ab 139,00 €
HDAC-8, active human recombinant protein
Artikelnummer: BPS-50008
Active humanHDAC8 , GenBank Accession No. NM_018486, full length with C-terminal His tag, MW= 42.4 kDa, expressed in a baculovirus expression system.
| Schlagworte: | HD8, CDA07, HDACL1, Histone deacetylase 8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 42.4 kD |
693,00 €
PCI 34051
Artikelnummer: Cay10444-10
PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 µM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 µM, respectively). PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4...
| Schlagworte: | N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide |
| Anwendung: | HDAC inhibitor |
| CAS | 950762-95-5 |
| MW: | 296.3 D |
ab 119,00 €
Romidepsin
Artikelnummer: Cay17130-500
Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent and selective inhibition of HDAC1, 2, 3, and 8 (IC50s =...
| Schlagworte: | FK228, FR901228, NSC 630176, cyclic... |
| Anwendung: | Class I HDAC inhibitor |
| CAS | 128517-07-7 |
| MW: | 540.7 D |
ab 169,00 €
HDAC8 (human, recombinant)
Artikelnummer: Cay19380-50
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the zinc-dependent deacetylation of core histones. It is composed of a single alpha/beta domain with an N-terminal deacetylase active site, which can be disrupted by phosphorylation of a proximal serine. HDAC8 is ubiquitously expressed in human tissues...
| Schlagworte: | HD8, HD8, HDAC8, CDA07, HDACL1, Histone deacetylase 8, Histone deacetylase 8 |
| Anwendung: | Enzyme activity |
| MW: | 45,3 kD |
652,00 €
HDAC8 Inhibitor Screening Assay Kit
Artikelnummer: Cay700230-96
Human HDAC8 is a class I HDAC and has been identified in a variety of human cancer tissues. Cayman's HDAC8 Inhibitor Screening Assay provides a convenient fluorescence-based method for screening HDAC8 inhibitors. The procedure requires only two easy steps, both performed in the same microplate. The fluorescent...
| Schlagworte: | Histone Deacetylase 8 Inhibitor Screening Assay Kit |
| Anwendung: | HDAC8 inhibitor screening |
| Spezies-Reaktivität: | human |
533,00 €
Fluorogenic HDAC8 Assay Kit
Artikelnummer: BPS-50068
The Fluorogenic HDAC8 Assay Kit is a complete assay system designed to measure histone deacetylases 8 (HDAC8) activity in cell extracts, nuclear extracts, immunoprecipitates, and purified enzymes. It comes in a convenient 96-well format, with all the reagents necessary for fluorescent HDAC activity measurements. In...
| Schlagworte: | HD8, CDA07, HDACL1, Histone deacetylase 8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8, |
| Anwendung: | HDAC8 assays, inhibitor screening, HTS |
700,00 €
UF010
Artikelnummer: Cay21273-5
UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 µM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 µM when screened against the...
| Schlagworte: | 4-bromo-benzoic acid, 2-butylhydrazide |
| Anwendung: | Class I HDAC inhibitor |
| CAS | 537672-41-6 |
| MW: | 271.2 D |
ab 69,00 €
HDAC8-IN-1
Artikelnummer: Cay28832-10
HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8, IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = >3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 µM, respectively).Formal Name:...
| Schlagworte: | MDK-7933, (2E)-N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide |
| Anwendung: | HDAC8 inhibitor |
| CAS | 1417997-93-3 |
| MW: | 345.4 D |
ab 69,00 €
HDAC8 Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPY-01333-100ug
Description: HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
| Schlagworte: | histone deacetylase 8, MRXS6, CDA07, HD8, HDACL1, CDLS5, RPD3, WTS |
| MW: | 68 kD |
568,00 €
Anti-phospho-HDAC8 (Ser39)
Artikelnummer: ARG51629.100
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
| Schlagworte: | Anti-phospho-HD8, Anti-phospho-CDA07, Anti-phospho-HDAC8, Anti-phospho-HDACL1, EC=3.5.1.98, Anti-phospho-Histone... |
| Anwendung: | ICC, IF, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €