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HDAC-8, active human recombinant protein
Artikelnummer: BPS-50008
Active humanHDAC8 , GenBank Accession No. NM_018486, full length with C-terminal His tag, MW= 42.4 kDa, expressed in a baculovirus expression system.
| Schlagworte: | HD8, CDA07, HDACL1, Histone deacetylase 8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 42.4 kD |
679,00 €
PCI 34051
Artikelnummer: Cay10444-10
PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 µM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 µM, respectively). PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4...
| Schlagworte: | N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide |
| Anwendung: | HDAC inhibitor |
| CAS | 950762-95-5 |
| MW: | 296.3 D |
ab 104,00 €
Romidepsin
Artikelnummer: Cay17130-500
Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent and selective inhibition of HDAC1, 2, 3, and 8 (IC50s =...
| Schlagworte: | FK228, FR901228, NSC 630176, cyclic... |
| Anwendung: | Class I HDAC inhibitor |
| CAS | 128517-07-7 |
| MW: | 540.7 D |
ab 147,00 €
HDAC8 (human, recombinant)
Artikelnummer: Cay19380-50
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the zinc-dependent deacetylation of core histones. It is composed of a single alpha/beta domain with an N-terminal deacetylase active site, which can be disrupted by phosphorylation of a proximal serine. HDAC8 is ubiquitously expressed in human tissues...
| Schlagworte: | HD8, HD8, HDAC8, CDA07, HDACL1, Histone deacetylase 8, Histone deacetylase 8 |
| Anwendung: | Enzyme activity |
| MW: | 45,3 kD |
571,00 €
HDAC8 Inhibitor Screening Assay Kit
Artikelnummer: Cay700230-96
Human HDAC8 is a class I HDAC and has been identified in a variety of human cancer tissues. Cayman's HDAC8 Inhibitor Screening Assay provides a convenient fluorescence-based method for screening HDAC8 inhibitors. The procedure requires only two easy steps, both performed in the same microplate. The fluorescent...
| Schlagworte: | Histone Deacetylase 8 Inhibitor Screening Assay Kit |
| Anwendung: | HDAC8 inhibitor screening |
| Spezies-Reaktivität: | human |
467,00 €
Fluorogenic HDAC8 Assay Kit
Artikelnummer: BPS-50068
The Fluorogenic HDAC8 Assay Kit is a complete assay system designed to measure histone deacetylases 8 (HDAC8) activity in cell extracts, nuclear extracts, immunoprecipitates, and purified enzymes. It comes in a convenient 96-well format, with all the reagents necessary for fluorescent HDAC activity measurements. In...
| Schlagworte: | HD8, CDA07, HDACL1, Histone deacetylase 8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8, |
| Anwendung: | HDAC8 assays, inhibitor screening, HTS |
657,00 €
UF010
Artikelnummer: Cay21273-5
UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 µM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 µM when screened against the...
| Schlagworte: | 4-bromo-benzoic acid, 2-butylhydrazide |
| Anwendung: | Class I HDAC inhibitor |
| CAS | 537672-41-6 |
| MW: | 271.2 D |
ab 60,00 €
HDAC8-IN-1
Artikelnummer: Cay28832-10
HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8, IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = >3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 µM, respectively).Formal Name:...
| Schlagworte: | MDK-7933, (2E)-N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide |
| Anwendung: | HDAC8 inhibitor |
| CAS | 1417997-93-3 |
| MW: | 345.4 D |
ab 60,00 €
Anti-phospho-HDAC8 (Ser39)
Artikelnummer: ARG51629.100
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...
| Schlagworte: | Anti-phospho-HD8, Anti-phospho-CDA07, Anti-phospho-HDAC8, Anti-phospho-HDACL1, EC=3.5.1.98, Anti-phospho-Histone... |
| Anwendung: | ICC, IF, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 436,00 €
Human Histone Deacetylase 8 / HDAC8 ELISA Kit
Artikelnummer: G-HUFI00995.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-HDAC8
Artikelnummer: NSJ-R30669
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid...
| Schlagworte: | Anti-HD8, Anti-HDAC8, Anti-CDA07, Anti-HDACL1, EC=3.5.1.98, Anti-Histone deacetylase 8, HDAC8 Antibody |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Droxinostat
Artikelnummer: BPS-27620-1
Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 ?M and 1.46 ?M, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.
| Schlagworte: | NS 41080, 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide, |
| Anwendung: | HDAC6/8 inhibitor |
| MW: | 243.7 D |
ab 350,00 €