Triciribine

Triciribine is an Akt activation inhibitor and a prodrug form of triciribine phosphate (Cay-37985). It reduces levels of phosphorylated Akt1, -2, and -3 in Akt-overexpressing NIH3T3 cells when used at a concentration of 1 µM. Triciribine is selective for Akt1, -2, and -3 over a panel of seven other Akt-activating kinases at 1 µM. It reduces the proliferation of L1210 mouse leukemia cells when used at concentrations of 0.05, 0.2, and 1 µM. Triciribine (1 µM) induces cell cycle arrest at the G1 phase in L1210 cells. It reduces viral plaque formation in CEM-SS cells and human foreskin fibroblasts (HFFs) infected with HIV-1 and human cytomegalovirus (CMV), respectively (IC50s = 0.02 and 2 µM, respectively). It inhibits tumor proliferation in an OVCAR-3 ovarian cancer mouse xenograft model when administered at a dose of 1 mg/kg per day.Formal Name: 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. CAS Number: 35943-35-2. Synonyms: API 2, NSC 154020, TCN, Tricyclic Nucleoside. Molecular Formula: C13H16N6O4. Formula Weight: 320.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 295 nm. SMILES: OC[C@H]1O[C@H](C(O)C1O)n1cc2c(N)nn(C)c3ncnc1c23. InChi Code: InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1. InChi Key: HOGVTUZUJGHKPL-HTVVRFAVSA-N.