TASIN-1

TASIN-1 is a small molecule inhibitor that specifically kills cells with adenomatous polyposis coli (APC) truncations (IC50 = 70 nM) but spares cells with wild-type APC. TASIN-1 is effective in vivo, inhibiting tumor growth of colorectal cancer (CRC) cells with truncated APC, but not wild-type CRC cells, in a mouse xenograft model. TASIN-1 decreases cholesterol biosynthesis in APC-truncated cells but not in wild-type APC cells.Formal Name: 1'-[(4-methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine. CAS Number: 792927-06-1. Molecular Formula: C18H28N2O3S. Formula Weight: 352.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 15 mg/ml, Ethanol: 25 mg/ml. lambdamax: 241 nm. SMILES: CC1CCN(C2CCN(S(C3=CC=C(OC)C=C3)(=O)=O)CC2)CC1. InChi Code: InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3. InChi Key: XCBHYDPDIJQQGM-UHFFFAOYSA-N.